• Do Not Take If

    Your child should not receive any formulation of LUPRON DEPOT-PED if he/she has experienced any type of allergic reaction to LUPRON DEPOT-PED or similar drugs.

    Females who are or may become pregnant should not receive any formulation of LUPRON DEPOT-PED.

    LUPRON DEPOT-PED is not for children under 2 years of age.

    View the full Prescribing Information for LUPRON DEPOT-PED.

    Reference: LUPRON DEPOT-PED [package insert]. North Chicago, IL: Abbott Laboratories.

    202-653313

  • Before Starting

    Talk to your child's doctor about your child's medical history and all other medicines that your child takes.

    Convulsions have been observed in patients taking leuprolide acetate, including patients who have a history of seizures, epilepsy, or brain disorders (related to blood vessels, nerves, or tumors), and in patients who are taking medications that have been associated with convulsions. Convulsions have also been reported in patients without any of these conditions.

    View the full Prescribing Information for LUPRON DEPOT-PED.

    Reference: LUPRON DEPOT-PED [package insert]. North Chicago, IL: Abbott Laboratories.

    202-653313

  • What to Expect

    During the first weeks of treatment, signs of puberty, such as vaginal bleeding, may occur. This is a common initial effect of the drug. Notify your child's doctor if signs/symptoms of puberty continue beyond the second month of treatment.

    After the injection, some pain and irritation is expected; however, if more severe symptoms occur or if any new, unusual, or worsened symptoms develop, contact your child's doctor.

    Your child's initial response to LUPRON DEPOT-PED should be monitored, as well as their continued response during treatment, as clinically needed.

    • If your child receives a 1-month injection, response is assessed 1–2 months after the initial injection.
    • If your child receives a 3-month injection, response is assessed 2–3 months after the initial injection and at month 6.
    • Height and bone age should be checked every 6–12 months in children using either formulation of LUPRON DEPOT-PED.

    It is important that you keep your child's doctor appointments and follow the prescribed injection schedule. Your child's pubertal development could begin again if injections are missed.

    View the full Prescribing Information for LUPRON DEPOT-PED.

    Reference: LUPRON DEPOT-PED [package insert]. North Chicago, IL: Abbott Laboratories.

    202-653313

  • Side Effects

    The most common side effects with LUPRON DEPOT-PED and similar drugs are pain; acne; injection site reactions, including pain, swelling, and abscess; rash, including a painful rash with fever, blisters/sores, and facial swelling; vaginitis/vaginal bleeding/vaginal discharge; increased weight; altered mood; general pain; headache; fluctuating emotions; and hot flushes/sweating.

    View the full Prescribing Information for LUPRON DEPOT-PED.

    Reference: LUPRON DEPOT-PED [package insert]. North Chicago, IL: Abbott Laboratories.

    202-653313

  • Helpful Resources

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

    If you cannot afford your medication, contact www.pparx.org or call the toll-free phone number (1-888-4PPANOW) for assistance.

    View the full Prescribing Information for LUPRON DEPOT-PED.

    Reference: LUPRON DEPOT-PED [package insert]. North Chicago, IL: Abbott Laboratories.

    202-653313

Print Safety Facts

LUPRON DEPOT-PED 7.5 mg, 11.25 mg and 15 mg for 1-month and 11.25 mg and 30 mg for 3-month administration are prescribed for the treatment of children with central precocious puberty (CPP).

Doctors may diagnose children with CPP when signs of sexual maturity begin to develop in girls under the age of 8 or boys under the age of 9. Your doctor should perform tests to rule out possible causes of CPP that would require different treatment (e.g., tumors).

LUPRON DEPOT-PED must be administered under the supervision of a physician.

Talking with Your Child about CPP

Learn how to answer your child’s questions and talk about CPP

Most children want to fit in with other children; they don’t want to be different. Children who begin puberty early may feel different from other children their age, which can cause social and emotional problems. As a parent, you also may have trouble dealing with your child's early development. Learning how to talk to your child and answer his or her questions can go a long way toward helping to make you and your child feel more comfortable with CPP and its treatment.1

Treat your child age appropriately

Due to CPP, your child may be taller than other children who are the same age. It is important that children with CPP are treated according to their actual age rather than their size. Children tend to behave according to how they are treated. Because he or she may physically look old enough to handle activities and situations more appropriate for an older child, it can be easy to forget your child’s emotional and mental maturity are still developing at milestones appropriate for his or her chronological age. Parents of children with precocious puberty should remind teachers, relatives, and friends about this important relationship.

Ways to reassure your child

Your child may feel embarrassed by the physical effects of puberty. Many children want to look and act like their friends. It is helpful to emphasize to your child that all girls and boys normally experience puberty, but in his or her case, it has occurred sooner than usual. It is important to tell your child that the changes in his or her body are normal. Your child should be allowed to participate in his or her usual activities, which may include spending the night with a friend, athletics, and extracurricular activities. Encourage your child to discuss any worries that he or she may be having.1

If you, your child, or other members of your family are having difficulty coping, seek counseling. Psychological counseling can help your family better understand and handle the emotions, issues, and challenges that accompany precocious puberty. If you have questions or would like guidance on how to find a qualified counselor, talk with your child’s physician.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you cannot afford your medication, contact www.pparx.org or call the toll-free number 1-888-477-2669.