Talk to your child's doctor about your child's medical history and all other medicines that your child takes.

Convulsions have been observed in patients taking leuprolide acetate, including patients who have a history of seizures, epilepsy, or brain disorders (related to blood vessels, nerves, or tumors), and in patients who are taking medications that have been associated with convulsions. Convulsions have also been reported in patients without any of these conditions.

View the full Prescribing Information for LUPRON DEPOT-PED.

Reference: LUPRON DEPOT-PED [package insert]. North Chicago, IL: Abbott Laboratories.

202-653313

During the first weeks of treatment, signs of puberty, such as vaginal bleeding, may occur. This is a common initial effect of the drug. Notify your child's doctor if signs/symptoms of puberty continue beyond the second month of treatment.

After the injection, some pain and irritation is expected; however, if more severe symptoms occur or if any new, unusual, or worsened symptoms develop, contact your child's doctor.

Your child's initial response to LUPRON DEPOT-PED should be monitored, as well as their continued response during treatment, as clinically needed.

• If your child receives a 1-month injection, response is assessed 1–2 months after the initial injection.
• If your child receives a 3-month injection, response is assessed 2–3 months after the initial injection and at month 6.
• Height and bone age should be checked every 6–12 months in children using either formulation of LUPRON DEPOT-PED.

It is important that you keep your child's doctor appointments and follow the prescribed injection schedule. Your child's pubertal development could begin again if injections are missed.

View the full Prescribing Information for LUPRON DEPOT-PED.

Reference: LUPRON DEPOT-PED [package insert]. North Chicago, IL: Abbott Laboratories.

202-653313

The most common side effects with LUPRON DEPOT-PED and similar drugs are pain; acne; injection site reactions, including pain, swelling, and abscess; rash, including a painful rash with fever, blisters/sores, and facial swelling; vaginitis/vaginal bleeding/vaginal discharge; increased weight; altered mood; general pain; headache; fluctuating emotions; and hot flushes/sweating.

View the full Prescribing Information for LUPRON DEPOT-PED.

Reference: LUPRON DEPOT-PED [package insert]. North Chicago, IL: Abbott Laboratories.

202-653313

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you cannot afford your medication, contact www.pparx.org or call the toll-free phone number (1-888-4PPANOW) for assistance.

View the full Prescribing Information for LUPRON DEPOT-PED.

Reference: LUPRON DEPOT-PED [package insert]. North Chicago, IL: Abbott Laboratories.

202-653313