How LUPRON DEPOT-PED Works
LUPRON DEPOT-PED suppresses puberty-causing hormones1-3
LUPRON DEPOT-PED belongs to a class of drugs called
gonadotropin-releasing hormone (GnRH) agonistsGonadotropin-releasing hormone (GnRH) agonist: The most common treatment for CPP. GnRH agonists work by making sure the pituitary gland stops sending hormones to stimulate the ovaries and testes to produce sex hormones.
This drug is similar to GnRHGonadotropin-releasing hormone (GnRH): a hormone made by the hypothalamus (part of the brain) that causes the pituitary gland (a small gland at the base of the brain) to release two other hormones: luteinizing hormone (LH) and follicle-stimulating hormone (FSH),
a hormoneHormone: a chemical substance produced in an organ of the body (like the adrenal glands or the pituitary gland) and carried to another organ or tissue in the body, where it has a specific effect
made naturally by your body.
When a child’s body is ready to begin pubertyPuberty: the period when a person begins to develop secondary sex characteristics and becomes capable of sexual reproduction,
a part of the brain called the hypothalamusHypothalamus: a part of the brain that regulates a number of basic body functions, like temperature, sleep, food intake, and the development of secondary sex characteristics
releases GnRH. GnRH causes the pituitary glandPituitary gland: a small gland located at the base of the brain that helps control the release of hormones
to release two other hormones: luteinizing hormone (LH)Luteinizing hormone (LH): a hormone released by the pituitary gland that stimulates the ovaries to produce estrogen and the testicles to produce testosterone—which lead to the changes you see during puberty
and follicle-stimulating hormone (FSH)Follicle-stimulating hormone (FSH): a hormone released by the pituitary gland that stimulates the ovaries to produce estrogen and the testicles to produce testosterone—which lead to the changes you see during puberty.
LH and FSH stimulate the ovaries to produce estrogenEstrogen: female sex hormone responsible for the development of secondary sex characteristics and involved in the reproductive cycle in women
or the testicles to produce testosteroneTestosterone: male sex hormone (a small amount is produced by females as well) that is responsible for producing masculine secondary sex characteristics such as growth of body hair and the development of the male reproductive system.—which
leads to the changes you see during puberty. In children with central precocious puberty (CPP), this process happens
earlier than normal.
LUPRON DEPOT-PED works by suppressing the natural GnRH hormone. This interrupts
the release of the hormones that cause puberty, until it is a more appropriate time for puberty to occur.
Safety Considerations: During the first weeks of treatment, an increase in the signs of puberty may
occur. This is a common initial effect of the drug. LUPRON DEPOT-PED can also cause unintended side effects
including general pain; acne; injection site reactions including pain, swelling, and abscess; rash including
a rash with fever and blister-like bumps; vaginitis/vaginal bleeding/vaginal discharge; increased weight;
headache; and changes in mood. Talk with your doctor about all the benefits and risks when deciding if LUPRON DEPOT-PED
is right for your child.
When LUPRON DEPOT-PED therapy stops, puberty starts back up1
Your pediatric endocrinologist will monitor your child’s progress during therapy. When the pediatric
endocrinologist decides that it’s a more appropriate time for puberty to continue, he or she will
discontinue treatment, and the puberty-causing hormones will no longer be suppressed. Normal puberty
development will then start back up.