LUPRON DEPOT-PED
HAS BEEN TRUSTED BY PARENTS AND DOCTORS
FOR OVER 30 YEARS
as the #1* prescribed treatment for kids with CPP
*Data sourced as of February 2023.

*Data sourced as of February 2023.
LUPRON DEPOT-PED helps control Central Precocious Puberty (CPP) by stopping the release of hormones that cause puberty.
In a study of 1-month dosing,‡ LUPRON DEPOT-PED provided control by pausing early puberty within 4 weeks.
96.4% of children achieved suppression of a reproductive hormone.§
Suppression means either pausing puberty with no changes or reversing the signs of puberty.
‡The study included 55 children (49 females and 6 males) with CPP treated with LUPRON DEPOT-PED for an average of 3.9 years who were then followed after treatment for an average of 3.5 years.
§Mean peak luteinizing hormone.
While on treatment, your child’s physical signs of early puberty should be paused.
Genital and breast development should stop or reverse. Your child’s growth should slow down to a rate that is normal for their age.
LUPRON DEPOT-PED was also studied as 3-month and 6-month dosing schedules and provided control, pausing early puberty within 4 weeks in children with CPP. Talk to your child’s doctor about what dose and schedule is best for your child.
Talk to your child’s pediatric endocrinologist about when it's appropriate for your child to start and stop treatment.
The pediatric endocrinologist can help decide what treatment plan may work best for your child’s specific needs.
In nearly 9 out of 10 children taking 1-month LUPRON DEPOT-PED, reproductive hormones returned to puberty levels within 6 months of stopping treatment
LUPRON DEPOT-PED is the only CPP treatment that has a long‑term, 18-year safety study.
80% (16 of 20)
reported normal menstrual cycles¶
12 pregnancies
in 7 patients (including multiple pregnancies in 4 patients)
4 of 4 women
who tried to become pregnant did
¶According to the Office on Women's Health, this is similar to women in the United States, with up to 86% having regular bleeding during their childbearing years.
LUPRON DEPOT-PED offers flexible dosing.
Your child's doctor can create a treatment plan specifically for your child. This will ensure they get the right amount of medicine throughout their treatment.
DOSING |
---|
3-month dosing |
11.25 mg and 30 mg |
4 injections each year |
1-month dosing |
7.5 mg, 11.25 mg, and 15 mg |
12 injections each year |
6-month dosing |
45 mg |
2 injections each year |
3-month dosing |
11.25 mg and 30 mg |
4 injections each year |
1-month dosing |
7.5 mg, 11.25 mg, and 15 mg |
12 injections each year |
Only LUPRON DEPOT-PED has 6 dosing options
How the dosing options work
Your child’s pediatric endocrinologist will monitor your child’s progress. If hormone and clinical suppression are not achieved with the starting dose, they may need to adjust the dose. The dose may also need to be adjusted as your child’s body weight changes.
Three-month dosing:
One-month dosing:
#After the injection, some pain and/or irritation may occur. However, if these symptoms get worse or persist, or if any new or unusual symptoms develop, call your child's doctor.
See additional Important Safety Information you should know about LUPRON DEPOT-PED.
You can also view the full Prescribing Information and talk with your child's doctor for more information.
LUPRON DEPOT-PED 7.5 mg, 11.25 mg, and 15 mg for 1-month, 11.25 mg and 30 mg for 3-month, and 45 mg for 6-month administration are prescribed for the treatment of children with central precocious puberty (CPP).
It is not known if LUPRON DEPOT-PED is safe and effective in children less than 1 year old.
What is the most important information I should know about LUPRON DEPOT-PED?
Call your child's doctor right away if your child has any new or worsening mental symptoms or problems while taking LUPRON DEPOT-PED.
Seizures have also happened in people who have not had any of these problems. Call your child's doctor right away if your child has a seizure while taking LUPRON DEPOT-PED.
LUPRON DEPOT-PED should not be taken if your child is:
Before your child receives LUPRON DEPOT-PED, tell their doctor about all of your child's medical conditions, including if they:
Tell your child's doctor about all the medicines your child takes, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
How will your child receive LUPRON DEPOT-PED?
What are the possible side effects of LUPRON DEPOT-PED?
LUPRON DEPOT-PED may cause serious side effects. See “What is the most important information I should know about LUPRON DEPOT-PED?”
These are not all the possible side effects of LUPRON DEPOT-PED. Call your child’s doctor for medical advice about side effects.
This is the most important information to know about LUPRON DEPOT-PED. For more information, talk to your child’s doctor or healthcare provider.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.
Please click here for full Prescribing Information.
US-LUPR-230025
How you act can also play a big role in helping reduce anxiety. If you’re anxious, your child will more likely be anxious. If you’re calm, your child will more likely be calm.
To reduce anxiety, you can tell jokes and make your child laugh by talking about funny things. Try not to talk about what the nurse is doing as they prepare the injection. Your child may become more distressed if you say sorry or tell them not to worry.