FOR OVER 30 YEARS

as the #1* prescribed treatment for kids with CPP

*Data sourced as of February 2023.

LUPRON DEPOT-PED helps control Central Precocious Puberty (CPP) by stopping the release of hormones that cause puberty.

LUPRON DEPOT-PED is:

A gonadotropin-releasing hormone, or GnRH, agonist. It works by helping the pituitary gland ignore signals from the brain. This, in turn, stops the release of sex hormones that cause puberty
The #1^† prescribed treatment for CPP by doctors in the US and has been used for over 30 years to help control early puberty
An intramuscular injection administered at the doctor’s office

^†Data sourced as of February 2023.

LUPRON DEPOT-PED treats CPP

In a study of 1-month dosing,^‡ LUPRON DEPOT-PED provided control by pausing early puberty within 4 weeks.

96.4% of children achieved suppression of a reproductive hormone.^§
Suppression means either pausing puberty with no changes or reversing the signs of puberty.

^‡The study included 55 children (49 females and 6 males) with CPP treated with LUPRON DEPOT-PED for an average of 3.9 years who were then followed after treatment for an average of 3.5 years.

^§Mean peak luteinizing hormone.

While on treatment, your child’s physical signs of early puberty should be paused.

Genital and breast development should stop or reverse. Your child’s growth should slow down to a rate that is normal for their age.

During 5 years of treatment, 66.7%–90.6% of females had suppression of breast development
During 5 years of treatment, 60%–100% of males had suppression of genitalia development

LUPRON DEPOT-PED was also studied as 3-month and 6-month dosing schedules and provided control, pausing early puberty within 4 weeks in children with CPP. Talk to your child’s doctor about what dose and schedule is best for your child.

Talk to your child’s pediatric endocrinologist about when it's appropriate for your child to start and stop treatment.

The pediatric endocrinologist can help decide what treatment plan may work best for your child’s specific needs.

In nearly 9 out of 10 children taking 1-month LUPRON DEPOT-PED, reproductive hormones returned to puberty levels within 6 months of stopping treatment

LUPRON DEPOT-PED is the only CPP treatment that has a long‑term, 18-year safety study.

LUPRON DEPOT-PED offers flexible dosing.

FLEXIBLE DOSING

Every child has unique needs, including the amount of medicine needed to treat their CPP

Your child's doctor can create a treatment plan specifically for your child. This will ensure they get the right amount of medicine throughout their treatment.

DOSING

3-month dosing

11.25 mg and 30 mg

4 injections each year

1-month dosing

7.5 mg, 11.25 mg, and 15 mg

12 injections each year

6-month dosing

45 mg

2 injections each year

3-month dosing

11.25 mg and 30 mg

4 injections each year

1-month dosing

7.5 mg, 11.25 mg, and 15 mg

12 injections each year

Only LUPRON DEPOT-PED has 6 dosing options

How the dosing options work

Your child’s doctor decides on the appropriate starting dose for your child
The doctor checks hormone levels at the appropriate time based on the dosing schedule
If the hormone levels are reduced, the doctor may change how often your child gets an injection
If the hormone levels are not reduced, the doctor may change how much medicine is given and/or how often your child gets an injection

Your child’s pediatric endocrinologist will monitor your child’s progress. If hormone and clinical suppression are not achieved with the starting dose, they may need to adjust the dose. The dose may also need to be adjusted as your child’s body weight changes.

COMMON
SIDE EFFECTS

Your healthcare team will assess your child for any side effects of treatment with LUPRON DEPOT-PED.

Possible side effects of LUPRON DEPOT-PED

It’s important to notify your child’s pediatrician or pediatric endocrinologist right away if your child experiences any side effects from therapy.

In clinical studies, the most common side effects of LUPRON DEPOT-PED included:

Six-month dosing:

Injection site reactions^# such as pain, swelling, and abscess
Headache
Mood changes
Upper stomach pain
Diarrhea
Bleeding
Nausea and vomiting
Fever
Itching
Pain in extremities

Rash
Back pain
Ligament sprain
Weight gain
Fracture
Breast tenderness
Difficulty sleeping
Chest pain
Excessive sweating

Three-month dosing:

Injection site reactions^# such as pain and swelling
Weight gain

Headache
Mood changes

One-month dosing:

Injection site reactions^# such as pain, swelling, and abscess
Weight gain
Pain throughout body
Headache

Acne or red, itchy rash and white scales (seborrhea)
Serious skin rash (erythema multiforme)
Mood changes
Swelling of vagina (vaginitis), vaginal bleeding, and vaginal discharge

Ask your child's doctor about possible side effects with LUPRON DEPOT-PED

^#After the injection, some pain and/or irritation may occur. However, if these symptoms get worse or persist, or if any new or unusual symptoms develop, call your child's doctor.

See additional Important Safety Information you should know about LUPRON DEPOT-PED.

You can also view the full Prescribing Information and talk with your child's doctor for more information.

Get started with LUPRON DEPOT-PED therapy

Get tips for preparing for the visit to your child's doctor’s office for treatment.

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Find information about CPP and LUPRON DEPOT-PED.

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Starting Therapy

LUPRON DEPOT-PED
HAS BEEN TRUSTED BY PARENTS AND DOCTORS

FOR OVER 30 YEARS

as the #1* prescribed treatment for kids with CPP

LUPRON DEPOT-PED is:

LUPRON DEPOT-PED treats CPP

LUPRON DEPOT-PED can help
control your child’s CPP

FLEXIBLE DOSING

Every child has unique needs, including the amount of medicine needed to treat their CPP

COMMON
SIDE EFFECTS

Ask your child's doctor about possible side effects with LUPRON DEPOT-PED

Get started with LUPRON DEPOT-PED therapy

Find help understanding your insurance coverage

Download
resources

Use for LUPRON DEPOT-PED^® (leuprolide acetate for depot suspension)

Important Safety Information for LUPRON DEPOT-PED

Important Safety Information

Important Safety Information

Important Safety Information

Important Safety Information

Use for LUPRON DEPOT-PED^® (leuprolide acetate for depot suspension)

Important Safety Information for LUPRON DEPOT-PED

LUPRON DEPOT-PED HAS BEEN TRUSTED BY PARENTS AND DOCTORS

FOR OVER 30 YEARS

as the #1* prescribed treatment for kids with CPP

LUPRON DEPOT-PED is:

LUPRON DEPOT-PED treats CPP

LUPRON DEPOT-PED can help control your child’s CPP

FLEXIBLE DOSING

Every child has unique needs, including the amount of medicine needed to treat their CPP

COMMON SIDE EFFECTS

Ask your child's doctor about possible side effects with LUPRON DEPOT-PED

Get started with LUPRON DEPOT-PED therapy

Find help understanding your insurance coverage

Download resources

Use for LUPRON DEPOT-PED® (leuprolide acetate for depot suspension)

Important Safety Information for LUPRON DEPOT-PED

Important Safety Information

Important Safety Information

Important Safety Information

Important Safety Information

Use for LUPRON DEPOT-PED® (leuprolide acetate for depot suspension)

Important Safety Information for LUPRON DEPOT-PED

LUPRON DEPOT-PED
HAS BEEN TRUSTED BY PARENTS AND DOCTORS

LUPRON DEPOT-PED can help
control your child’s CPP

COMMON
SIDE EFFECTS

Download
resources

Use for LUPRON DEPOT-PED^® (leuprolide acetate for depot suspension)

Use for LUPRON DEPOT-PED^® (leuprolide acetate for depot suspension)