START AND STAYON LUPRON DEPOT-PEDTO CONTROL YOUR CHILD'S CENTRAL PRECOCIOUS PUBERTY (CPP)

Once you and your child's doctor decide on treatment, the prescription will be sent to your insurance provider to determine costs. If you have any questions or concerns regarding coverage, Support PLUS can help.

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Get ready for the visit to your child's doctor and learn about what to expect when you get there.

TIPS FOR DOCTOR VISIT

Before Before

During During

After After

Help your child relax on the way to the doctor by playing a game or making up a song.

In the waiting room, having cards, a book, or something that can help distract your child can help ease some of the anxiety.

In the exam room, the nurse or medical assistant will prep your child for the injection.

The nurse may do an activity to help your child relax their muscles.

The injection site can vary between the upper arm, buttocks, or thigh to make the experience easier for your child.

After the injection, some pain and irritation at the site is expected. However, if more severe symptoms occur or if any new, unusual, or worsened symptoms develop, contact your child's doctor right away.

Helpful ways to distract your child if they are feeling anxious

Look out for signs that your child’s dose may need to change.

LOOK OUT FOR SIGNS

After your child starts therapy, they may first show more signs of puberty. Don’t worry! This is normal.

After the first few weeks, your child will stop producing the hormones causing their CPP and you should begin to see the signs of puberty slow down and then eventually stop.

Your healthcare team will assess your child for any side effects of treatment with LUPRON DEPOT-PED.

Month 1: After starting therapy, your child may first show increased signs and symptoms of CPP–this is normal.

It is a common initial effect of the drug to see an increase in the signs or symptoms of puberty during the first weeks of treatment. These symptoms should go away. If they continue beyond the second month, tell your child's doctor.

After month 1: After the first few weeks, the hormones causing your child's CPP should be suppressed and you should begin to see the signs of puberty slow down and then eventually stop.

Tell your child's pediatric endocrinologist immediately if:

Your daughter has menstrual bleeding that keeps going after the second month of treatment
You see irritation at the injection site
Your child has a seizure or develops new or worsened mental (psychiatric) symptoms or problems
Your child has any of the following symptoms during treatment: headache, eye problems (including blurred vision, double vision, and decreased eyesight), eye pain, ringing in the ears, dizziness or nausea

While on LUPRON DEPOT-PED, your child’s growth should slow down to a rate that is normal for their age. For girls, breast development will stop and may regress. For boys, the penis and testicles may shrink back to a size that is normal for their age.

Some people taking gonadotropin-releasing hormone (GnRH) agonists like LUPRON DEPOT-PED have had new or worsened mental (psychiatric) problems.

Mental (psychiatric) problems may include emotional symptoms such as:

Crying
Irritability

Restlessness (impatience)
Anger

Acting aggressive

The risk of seizures may be higher in people who have a history of seizures, epilepsy, brain or brain vessel (cerebrovascular) problems or tumors, or in people who are taking a medicine that has been connected to seizures, such as bupropion or selective serotonin reuptake inhibitors (SSRIs).

Seizures have also happened in people who have not had any of these problems.

Increased pressure in the fluid around the brain can happen in children taking GnRH agonist medicines, including LUPRON DEPOT-PED.

Call your child’s doctor right away if your child experiences any of the following while taking LUPRON DEPOT-PED:

Any new or worsened mental (psychiatric) symptoms or problems
Seizure
Any of the following symptoms: headache, eye problems (including blurred vision, double vision, and decreased eyesight), eye pain, ringing in the ears, dizziness, or nausea

See tips for starting your child on treatment.

MONITORING TREATMENT

After you and your child’s doctor choose a treatment schedule for your child, it’s important to commit to it.

Make appointments for the year in advance. This helps you plan events around the appointments with plenty of notice.

Talk to your child's doctor about scheduling options. If it’s hard to get to appointments during regular office hours, tell your doctor. Some offices can work with your schedule.

Make visits a special time with your child. Plan a little something extra for the day or an adventure to go on to make it an event you and your child can look forward to.

You can help monitor your child's treatment progress along with your child’s doctor

You know your child best. If you see changes in your child, let your child's doctor know. It’s important to be aware of the possible side effects of LUPRON DEPOT-PED so you know what to look out for. The changes may be in your child’s body or their behavior. Keeping appointments gives you a good way to talk to your child's doctor about how your child is responding to treatment.

Your child's pediatric endocrinologist will monitor your child’s progress during therapy. When they reach the age when puberty should occur, the doctor will stop your child's treatment to allow their puberty to start back up again.

When is the right time to stop treatment?

Each child is different. Talk to your child’s doctor about the best time for them to finish treatment. Patients who were treated with LUPRON DEPOT-PED were followed into adulthood. On average, they were taller than the height that was predicted for them when they were first diagnosed with CPP as children.

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Support PLUS and Resources

START AND STAYON LUPRON DEPOT-PEDTO CONTROL YOUR CHILD'S CENTRAL PRECOCIOUS PUBERTY (CPP)

TIPS FOR DOCTOR VISIT

LOOK OUT FOR SIGNS

After your child starts therapy, they may first show more signs of puberty. Don’t worry! This is normal.

MONITORING TREATMENT

You can help monitor your child's treatment progress along with your child’s doctor

When is the right time to stop treatment?

Find help navigating insurance

Need help talking about CPP?

Sign up for updates

Use for LUPRON DEPOT-PED^® (leuprolide acetate for depot suspension)

Important Safety Information for LUPRON DEPOT-PED

Important Safety Information for LUPRON DEPOT-PED

Important Safety Information for LUPRON DEPOT-PED

Important Safety Information for LUPRON DEPOT-PED

Important Safety Information for LUPRON DEPOT-PED

Use for LUPRON DEPOT-PED^® (leuprolide acetate for depot suspension)

Important Safety Information for LUPRON DEPOT-PED

START AND STAYON LUPRON DEPOT-PEDTO CONTROL YOUR CHILD'S CENTRAL PRECOCIOUS PUBERTY (CPP)

TIPS FOR DOCTOR VISIT

LOOK OUT FOR SIGNS

After your child starts therapy, they may first show more signs of puberty. Don’t worry! This is normal.

MONITORING TREATMENT

You can help monitor your child's treatment progress along with your child’s doctor

When is the right time to stop treatment?

Find help navigating insurance

Need help talking about CPP?

Sign up for updates

Use for LUPRON DEPOT-PED® (leuprolide acetate for depot suspension)

Important Safety Information for LUPRON DEPOT-PED

Important Safety Information for LUPRON DEPOT-PED

Important Safety Information for LUPRON DEPOT-PED

Important Safety Information for LUPRON DEPOT-PED

Important Safety Information for LUPRON DEPOT-PED

Use for LUPRON DEPOT-PED® (leuprolide acetate for depot suspension)

Important Safety Information for LUPRON DEPOT-PED

Use for LUPRON DEPOT-PED^® (leuprolide acetate for depot suspension)

Use for LUPRON DEPOT-PED^® (leuprolide acetate for depot suspension)