- CPP is when puberty starts sooner than it should. For girls, that’s before the age of 8, and for boys, before the age of 9.
- The common signs of CPP are the same as puberty, but they start earlier than usual.
- For girls, signs include breast bud development, menstrual periods, pubic or underarm hair, oily skin/acne, adult body odor, a sudden growth spurt, and irritability/mood swings
- For boys, the signs include testicle and penis enlargement, erections, voice change, facial hair, pubic or underarm hair, oily skin/acne, adult body odor, a sudden growth spurt, and irritability/mood swings
- If you notice any signs or symptoms of puberty occurring too soon, talk to your child’s pediatrician. Let them know what you have noticed. The pediatrician can refer you to a pediatric endocrinologist who can diagnose your child, and if appropriate, work out an individualized treatment plan for them.
- LUPRON DEPOT-PED is a gonadotropin-releasing hormone, or GnRH, agonist. It works by helping the pituitary gland ignore signals from the brain, which stops the release of sex hormones. LUPRON DEPOT-PED is prescribed for the treatment of children with CPP.
- LUPRON DEPOT-PED is a gonadotropin-releasing hormone, or GnRH, agonist. It works by helping the pituitary gland ignore signals from the brain, which stops the release of sex hormones.
- If CPP is left untreated, your child will keep going through puberty and that can have lasting complications beyond childhood. CPP causes an early growth spurt that can cause the bones to mature more quickly than normal and the growth plates to close too early. This can result in shorter adult height.
Children with CPP may look older than they are. This can affect how they feel and cope as they are often too young to understand what's happening with their bodies.
- LUPRON DEPOT-PED is injected into the muscle. The pediatric endocrinologist decides if your child should get an injection every 4 weeks or every 12 weeks. They may switch the injection site between the upper arm, buttocks, or thigh. With multiple dosing options available, the pediatric endocrinologist can choose the right dose of LUPRON DEPOT-PED for your child.
- It is a common initial effect of the drug to see an increase in the signs or symptoms of puberty, such as vaginal bleeding, during the first weeks of treatment. These symptoms should go away. If they continue beyond the second month, tell your child's doctor.
Some people taking gonadotropin-releasing hormone (GnRH) agonists like LUPRON DEPOT-PED have had new or worsened mental (psychiatric) problems. Mental (psychiatric) problems may include emotional symptoms, such as crying, irritability, restlessness (impatience), anger, and aggression.
Some people taking GnRH agonists like LUPRON DEPOT-PED have had seizures. The risk of seizures may be higher in people who have a history of seizures, epilepsy, brain or brain vessel (cerebrovascular) problems or tumors, or are taking a medicine that has been connected to seizures, such as bupropion or selective serotonin reuptake inhibitors (SSRIs). Seizures have happened in people who have not had any of these problems.
Increased pressure in the fluid around the brain can happen in children taking GnRH agonist medicines, including LUPRON DEPOT-PED.
Call your child’s doctor right away if your child experiences any of the following while taking LUPRON DEPOT-PED:
- Any new or worsened mental (psychiatric) symptoms or problems
- Any of the following symptoms: headache, eye problems (including blurred vision, double vision, and decreased eyesight), eye pain, ringing in the ears, dizziness, or nausea
The most common side effects of LUPRON DEPOT-PED received every 3 months include:
These are not all the possible side effects of LUPRON DEPOT-PED. Call your child's doctor for medical advice about side effects.
#After the injection, some pain and irritation is expected; however, if more severe symptoms occur or if any new, unusual, or worsening symptoms develop, contact your child's doctor right away.
that you should know about LUPRON DEPOT-PED.
You can also view the
and talk with your child's doctor for more information.
- Each child is different. Your child's pediatric endocrinologist will monitor your child’s progress during therapy. When they reach the age when puberty should occur, the doctor will stop treatment, allowing puberty to start back up again. Patients who were treated with LUPRON DEPOT-PED were followed into adulthood. On average, they were taller than the height that was predicted for them when they were first diagnosed with CPP as children.
- LUPRON DEPOT-PED has been prescribed for the treatment of CPP by doctors for over 25 years. Learn more about the results from the studies of LUPRON DEPOT-PED, including a long‑term, 18-year safety study.
- Don’t wait—act now. If you’re worried that your child may have CPP, speak with your child’s pediatrician as soon as you can. Let them know your concerns. If you want to be sure, ask for a referral to a pediatric endocrinologist. They can evaluate your child and confirm an appropriate diagnosis and treatment plan for them.
- To get a CPP diagnosis, you must take your child to see a pediatric endocrinologist. A pediatric endocrinologist is a doctor who specializes in the treatment of hormone-related conditions in children. Your child’s pediatrician can perform a physical exam of your child and measure their height and weight. They can compare your child’s growth with normal childhood development. However, only a pediatric endocrinologist can do the tests to confirm if your child has CPP.