LUPRON DEPOT-PED works by suppressing the release of puberty‑causing hormones.2

LUPRON DEPOT-PED is a gonadotropin-releasing hormone (GnRH) agonist. It’s a medicine that is similar to GnRH, a hormone made naturally by your body. LUPRON DEPOT-PED works by suppressing the natural GnRH hormone. This interrupts the release of the hormones that cause puberty until it is a more appropriate time for puberty to occur.

When LUPRON DEPOT-PED therapy stops, puberty starts back up.2

Your pediatric endocrinologist will monitor your child’s progress during therapy. Then, when he or she reaches the age when puberty should occur, the doctor will stop treatment and puberty will start back up again.

Want to learn more about how puberty begins?

 

Here's a quick lesson.

Treating with LUPRON DEPOT-PED2

LUPRON DEPOT-PED offers 3-month and 1-month individualized dosing options.

Every child has unique needs—including the amount of medicine needed to treat CPP.

With LUPRON DEPOT-PED, your doctor can create a treatment plan specific to your child’s needs so he or she gets the right amount of medicine for the right number of months.

Your pediatric endocrinologist will monitor your child’s progress. If hormone and clinical suppression are not achieved with the starting dose, he or she may need to adjust the dose. It may also need to be adjusted as your child’s body weight changes.
 

3

month dosing

3-month dosing| 11.25 mg and 30 mg

With 3-month dosing, your child only needs 4 injections per year. Your regularly scheduled doctor’s visits could coincide with your child’s injections so they fit your schedule.

Three month dosing plan for LUPRON DEPOT-PED (leuprolide acetate for depot suspension)

Having 4 visits a year also gives your doctor every chance to monitor your child’s CPP treatment along the way and make any adjustments needed. Typically, the doctor will want to check your child’s response 2–3 months after the first injection and again at month 6. Your doctor may also want to measure bone age every 6–12 months.

1

month dosing

1-month dosing |7.5 mg, 11.25 mg, and 15 mg

With 1-month dosing your child will receive 12 injections per year. During the first 2 months your doctor will assess your child’s response to the medication, and may want to measure bone age every 6–12 months.


A missed dose of LUPRON DEPOT‑PED can cause CPP to start up again.2
 

Keeping your appointments helps keep your child on track for treating CPP.

It is important that you keep all your child’s doctor appointments because regular visits let your doctor monitor your child’s progress and adjust the dose if needed.2

Plan. Monitor. Track with the CPP Tracker App at no charge to you. 

Want a step-by-step plan for your CPP Journey?

Download our “Facing Central Precocious Puberty” brochure  

LUPRON DEPOT-PED is the only CPP treatment that has a long‑term study3

As a parent, it’s natural to wonder about the future effects of medicines that your child takes. An 18-year study of the LUPRON DEPOT-PED 1-month formulation was conducted to examine the long-term impact on growth patterns and reproductive function of children treated for CPP.

During the first 5 years of treatment, the clinical signs of puberty were stopped in most children. Average growth rates decreased as well.

In about 88% of children, hormones returned to pubertal levels by 6 months after stopping treatment.

Patients who were treated with LUPRON DEPOT-PED and were then followed until they reached adulthood, on average, were taller than the height that was predicted for them when they were initially diagnosed with CPP as children.

The average age when girls started getting menstrual periods (or restarted, if they had already had them) was 12.9 years.

Some patients who were treated with LUPRON DEPOT-PED and then followed until they reached adulthood, reported pregnancies. Twelve pregnancies were reported in a post-treatment survey, including multiple pregnancies in 4 women.

Side Effects/Effects of Treatment2

How your child should respond to treatment with LUPRON DEPOT-PED2

Since LUPRON DEPOT-PED works by interfering with the production of hormones that cause puberty, after the first month of treatment, your child’s signs of puberty should slow or stop. For girls, breast development will stop and may regress. For boys, the penis and testicles may shrink back to a size that is normal for their age.

While on LUPRON DEPOT-PED, your child’s growth rate should be more like other children of the same age.

After starting LUPRON DEPOT-PED therapy, your child may show increased signs and symptoms of CPP during the first few weeks of treatment. That’s normal, so don’t worry. It’s due to the way the medicine works. After the first few weeks, your child will stop making some hormones and you may see pubertal changes stop or slow down.2

Side effects of CPP treatment

Certain signs to look out for2:

It is important to notify your pediatric endocrinologist right away if your child has:

  • Vaginal bleeding that continues beyond the second month of treatment
  • Irritation at the injection site
  • New or worsening mental (psychiatric) symptoms or problems
  • A seizure

Possible side effects of LUPRON DEPOT-PED2

It’s important to notify your pediatrician or pediatric endocrinologist right away if your child experiences any side effects from therapy. In clinical studies, the most common side effects of LUPRON DEPOT-PED received 1 time each month include:

  • Injection site reactions such as pain, swelling, and abscess
  • Weight gain
  • Pain throughout body
  • Headache
  • Acne or red, itchy, rash, and white scales (seborrhea)
  • Serious skin rash (erythema multiforme)
  • Mood changes
  • Swelling of vagina (vaginitis), vaginal bleeding, and vaginal discharge

The most common side effects of LUPRON DEPOT-PED received every 3 months include:

  • Injection site pain
  • Weight gain
  • Headache
  • Mood changes
  • Injection site swelling

These are not all the possible side effects of LUPRON DEPOT-PED.  Call your child's doctor for medical advice about side effects.

After the injection, some pain and irritation is expected; however, if more severe symptoms occur or if any new, unusual or worsening symptoms develop, contact your child's doctor right away.

See additional Important Safety Information you should know about LUPRON DEPOT-PED. You can also view the full Prescribing Information and talk with your doctor for more information.

References:

  1. IMS Health, IMS National Prescription Audit, June 2016.  2. LUPRON DEPOT-PED® [package insert]. North Chicago, IL: AbbVie Inc.  3. Lee PA, Neely EK, Fuqua J, et al. Efficacy of leuprolide acetate 1-month depot for central precocious puberty (CPP): Growth outcomes during a prospective, longitudinal study. Int J Pediatr Endocrinol. 2011;2011(1):7. Doi: 10.1186/1687/9856/2011/7. Epub 2011 Jul 12.